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MYP_141611
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Basic Information
CPF-C1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
17 amino acids
C77H132N22O20
Standard
Sequence
GFGSLLGKALRLGANVL
Physicochemical Analysis
1686.01 Da
11.00
1.76
1.55
0.1035
0.90
0.61
0.34
10.75
143.53
0.0588
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
680.16
-5.89
24.0
22.0
57.0
119.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134854 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 29.4%, E 0.0%, T 35.3%, C 35.3% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0162964 VERIFIED: NO
Provenance & Taxonomy
Eritrea clawed [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0163602 VERIFIED: YES
Provenance & Taxonomy
Xenopus clivii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii 2982
4 μg/mL
MIC
PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0164363 VERIFIED: YES
Provenance & Taxonomy
Tetraploid frog [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli 804
8 μg/mL
MIC
PaperNovel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria. Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988. PMID: 28371431. PMID28371431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28371431/
RECORD: Rec_0167608 VERIFIED: YES
Provenance & Taxonomy
Xenopus clivii [Animal]
CPF
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
6.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 153 (2011) 350-354. Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae)
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