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MYP_141577
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Basic Information
CAP7 (C-terminal fragment of CAP18; lagomorphs, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
37 amino acids
C204H352N64O47
Standard
Sequence
GLRKRLRKFRNKIKEKLKKIGQKIQGFVPKLAPRTDY
Physicochemical Analysis
4453.38 Da
11.54
11.75
11.53
0.3177
-1.11
0.67
-0.43
31.00
84.32
0.0811
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1881.35
-14.21
67.0
59.0
162.0
315.0
5.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0193130 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ML-35p
0.05 μM
MIC
PaperPubMed PMID: 8132348 | PubMed PMID: 10768969 | PubMed PMID: 7649303 PMID8132348;10768969;7649303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8132348/
RECORD: Rec_0206362 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
cathelicidin family
9986; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial cathelicidin family Antibacterial Host defense
PaperPDB 1LYP structural record; NMR; chain A; residues 1-32
RECORD: Rec_0237760 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
[100 mM NaCl]: Escherichia coli DH5a
0.21 μM
MIC
PaperPubMed PMID: 8132348 | PubMed PMID: 10768969 | PubMed PMID: 7649303 PMID8132348;10768969;7649303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8132348/
RECORD: Rec_0248933 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ML-35p
0.09 μM
MIC
PaperPubMed PMID: 8132348 | PubMed PMID: 10768969 | PubMed PMID: 7649303 PMID8132348;10768969;7649303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8132348/
RECORD: Rec_0275941 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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