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MYP_141577
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Basic Information
CAP7 (C-terminal fragment of CAP18; lagomorphs, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
37 amino acids
C204H352N64O47
Standard
Sequence
GLRKRLRKFRNKIKEKLKKIGQKIQGFVPKLAPRTDY
Physicochemical Analysis
4453.38 Da
11.54
11.75
11.53
0.3177
-1.11
0.67
-0.43
31.00
84.32
0.0811
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1881.35
-14.21
67.0
59.0
162.0
315.0
5.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044483 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa PAO1 at a MIC 14.8 uM (cf. full length CAP18, MIC was 0.22 uM) (Travis SM et al. 2000 Infect Immunity 68: 2748-55). Updated 12/2011; 6/2019; Jan2023; 11/2024
PaperAntimicrobial activity of rabbit CAP18-derived peptides
RECORD: Rec_0075809 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
[No NaCl]: Escherichia coli DH5a
0.19 μM
MIC
PaperPubMed PMID: 8132348 | PubMed PMID: 10768969 | PubMed PMID: 7649303 PMID8132348;10768969;7649303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8132348/
RECORD: Rec_0135940 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0171199 VERIFIED: NO
Provenance & Taxonomy
Mammalia [Animal]
40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0192796 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperChen C., Brock R., Luh F., Chou P.-J., Larrick J.W., Huang R.-F., Huang T.-H.;. "The solution structure of the active domain of CAP18 - a lipopolysaccharide binding protein from rabbit leukocytes."; FEBS Lett. 370:46-52. Evidence URLhttps://www.uniprot.org/uniprotkb/CP18_RABIT/entry
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