Peptide Database

Peptide NamePen a 1 tropomyosin-derived epitope

Function Ontology

Immunology ▸ Adverse immune reactivity ▸ Allergenicity ▸ Allergen-specific CD4 T-cell epitope

Immunology ▸ Epitope/vaccine antigen ▸ T-cell epitope ▸ Allergen-specific CD4 T-cell epitope

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC75H132N26O27S

DescriptionStandard

        RKVLENRSLSDEERM
    

Molecular Weight1862.07 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-0.23

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0154

GRAVY Index-1.52

Hydrophobic Moment 0.45

Boman Index-0.63

Instability Index54.70

Aliphatic Index 71.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 915.19

LogP -10.47

H-bond Donors 33.0

H-bond Acceptors 28.0

Rotatable Bonds 68.0

Heavy Atoms 129.0

Ring Count 0.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0130480 VERIFIED: YES

Provenance & Taxonomy

OrganismPenaeus aztecus [Animal]

FamilyTropomyosin

Tax ID6690.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory Allergen-specific CD4 T-cell epitope

TargetHuman CD4 T cells (shrimp-allergic subjects)

MethodMHC-peptide binding assay; CFSE dilution; tritiated-thymidine incorporation; cytokine release assay

PaperEugene V Ravkov et al. Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes. Hum Immunol. 2013. PMID: 23993987. https://pubmed.ncbi.nlm.nih.gov/23993987/ ; https://pmc.ncbi.nlm.nih.gov/articles/PMC3870591/ PMID23993987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23993987/

RECORD: Rec_0234862 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory