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MYP_141446
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Basic Information
ACE2 (352-359)(SAP4)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
8 amino acids
C41H68N12O11
Standard
Sequence
GKGDFRIL
Physicochemical Analysis
905.05 Da
8.75
0.76
0.56
0.0950
-0.20
0.56
-0.04
2.17
97.50
0.1250
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
392.24
-2.74
14.0
12.0
31.0
64.0
1.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0162563 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0245774 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | 293T/ACE2 cells
7500 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0276029 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
7.5 μM
IC50
PaperRationally designed ACE2-derived peptides inhibit SARS-CoV-2 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0356647 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells
7500 μM
IC50
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/