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MYP_141440
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Basic Information
LL-37 (17-29) [R23I,D26K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C82H141N23O15
Standard
Sequence
FKRIVQIIKKFLR
Physicochemical Analysis
1689.14 Da
12.00
4.76
4.55
0.3659
0.22
0.99
-0.13
24.50
142.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
657.47
-1.28
24.0
20.0
61.0
120.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046904 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
DLF lung fibroblasts
27 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0055541 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
20 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0059228 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
361 μg/mL
HC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0129993 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
20 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0269409 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
292 μg/mL
HC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
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