Peptide Database

Peptide NameAtrial natriuretic peptide (ANP)

Function Ontology

Binding / Molecular interaction ▸ Binding activity

Cardiovascular

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC127H205N45O39S3

DescriptionStandard

        SLRRSSCFGGRMDRIGAQSGLGCNSFRY
    

Molecular Weight3082.46 Da

Isoelectric Point (pI)10.66

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.1229

GRAVY Index-0.50

Hydrophobic Moment 0.60

Boman Index-0.20

Instability Index82.88

Aliphatic Index 45.36

Aromaticity 0.1071

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1403.38

LogP -20.26

H-bond Donors 55.0

H-bond Acceptors 46.0

Rotatable Bonds 104.0

Heavy Atoms 214.0

Ring Count 3.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409330 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-23

Bio-Activity Profile

Function

Natriuretic Vasodilator

MethodRadioimmunoassay

Half-LifeHuman plasma (Chronic renal diseases), in vivo; 288 s

RECORD: Rec_0420115 VERIFIED: YES