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MYP_141420
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Basic Information
Atrial natriuretic peptide (ANP)
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
28 amino acids
C127H205N45O39S3
Standard
Sequence
SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Physicochemical Analysis
3082.46 Da
10.66
3.44
3.20
0.1229
-0.50
0.60
-0.20
82.88
45.36
0.1071
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1403.38
-20.26
55.0
46.0
104.0
214.0
3.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0310549 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 14.3%, E 0.0%, T 35.7%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0320033 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Bos taurus [Animal]; Canis familiaris [Animal]; Equus caballus [Animal]; Sus scrofa [Animal]; Ovis aries [Animal]; Felis catus [Animal]
9606, 9913, 9615, 9796, 9823, 9940
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
7-23
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0321327 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Radioiodinated peptide at Tyr
Bio-Activity Profile
Natriuretic
RP-HPLC
Male Sprague-Dawley rats (nephrectomized rat) plasma (Dose i/p injected), in vivo; 25.2 s
PMID2942845 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2942845/
RECORD: Rec_0329501 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Natriuretic peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
Radioimmunoassay
Exogenously administered to Male SHR-SP/Izm rats treated with carvedilol, in vivo; 48 s
PMID9421401 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9421401/
RECORD: Rec_0355651 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Atrial natriuretic factor
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
noncanonical stereochemical modification [Modified]
7-23
6:Phosphoserine
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 22 minutes; /1320 seconds; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Atrial natriuretic factor (Homo sapiens): PMID 2942845 PMID2942845 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2942845/
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