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MYP_141420
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Basic Information
Atrial natriuretic peptide (ANP)
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
28 amino acids
C127H205N45O39S3
Standard
Sequence
SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Physicochemical Analysis
3082.46 Da
10.66
3.44
3.20
0.1229
-0.50
0.60
-0.20
82.88
45.36
0.1071
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1403.38
-20.26
55.0
46.0
104.0
214.0
3.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0159708 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Natriuretic peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Natriuretic Vasodilator
Radioimmunoassay
Human serum, in vivo; 246 s
PMID8388403 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8388403/
RECORD: Rec_0174304 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Bio-Activity Profile
Regulator of sodium ions in heart
Competitive Radioimmunoassay
Rat plasma (Subcutaneous), in vivo; 672 s
RECORD: Rec_0181829 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Bio-Activity Profile
Natriuretic Vasodilator
142±28 μM
Radioimmunoassay
Human plasma(younger, 20-39 years old), in vivo; 258 s
PMID1651738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1651738/
RECORD: Rec_0186585 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Natriuretic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Bio-Activity Profile
Natriuretic Vasodilator
ELISA
Female Wistar rats Plasma, in vivo; 210 s
PMID22263969 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22263969/
RECORD: Rec_0212040 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Bio-Activity Profile
Natriuretic
0.0024 μM
IC50
Human kidney membranes, in vitro; 156 s
PMID19458086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19458086/
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