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MYP_141420
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Basic Information
Atrial natriuretic peptide (ANP)
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
28 amino acids
C127H205N45O39S3
Standard
Sequence
SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Physicochemical Analysis
3082.46 Da
10.66
3.44
3.20
0.1229
-0.50
0.60
-0.20
82.88
45.36
0.1071
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1403.38
-20.26
55.0
46.0
104.0
214.0
3.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007057 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Receptor-binding
receptor binding
Kd
Infused in pulmonary artery of sheep, in vivo; 180 s
PMID11054637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11054637/
RECORD: Rec_0009603 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
natriuretic peptide family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-23
Bio-Activity Profile
Hormone natriuretic peptide family Neuropeptide signaling
PaperPDB 1YK0 structural record; X-ray; 2.40 A; chain E; residues 6-26
RECORD: Rec_0010681 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Natriuretic peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Natriuretic Vasodilator
in vitro; 102 s
PMID8076909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8076909/
RECORD: Rec_0022314 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Natriuretic peptide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-23
Iodinated at Tyr
Bio-Activity Profile
Natriuretic Vasodilator
Radioimmunoassay
Male Wistar rats plasma (Dose i/p injected), in vivo; 20.2 s
PMID1646465 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1646465/
RECORD: Rec_0037422 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
Natriuretic peptide
9940
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
7-23
Bio-Activity Profile
Hormone Cardiovascular
PMID3007908 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3007908/
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