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MYP_141401
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Basic Information
HCVB(1484-1500)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition
Standard
17 amino acids
C81H145N39O23
Standard
Sequence
STQRRGRTGRGRRGIYR
Physicochemical Analysis
2033.27 Da
12.00
6.46
6.25
0.3799
-2.09
0.60
-0.90
37.45
22.94
0.0588
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1086.23
-16.46
44.0
30.0
71.0
143.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003458 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-JEV Helicase inhibition
Japanese encephalitis virus NS3 helicase
47.2±4.7 μM
IC50 / NS3 helicase inhibition
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 Jul 1;76(1):28-38. | DOI:10.1016/j.bcp.2008.03.018 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0104161 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 23.5%, T 41.2%, C 35.3% [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0108713 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Hepatitis C virus NS3 helicase
24.3 μM
IC50 / NS3 helicase inhibition
PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0162310 VERIFIED: YES
Provenance & Taxonomy
West Nile virus [Virus]
Virus-derived peptide
11082;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
West Nile virus NS3 helicase
33.6 μM
IC50 / NS3 helicase inhibition
PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0172451 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus NS3 helicase
24.3±1.8 μM
IC50 / NS3 helicase inhibition
PaperPubMed PMID: 18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
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