Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length79 amino acids

Chemical FormulaC375H624N114O114S7

DescriptionStandard

        GQKSCWIIKGHCRKNCKSGEQVKKPCKNGDYCCILSKTDSQPHRLTQAPTGKSQILSTDLEGNDVLEHVPLVIMRQGKI
    

Molecular Weight8778.12 Da

Isoelectric Point (pI)9.17

Net Charge (pH 7.0)5.96

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.0755

GRAVY Index-0.66

Hydrophobic Moment 0.57

Boman Index-0.15

Instability Index24.54

Aliphatic Index 75.19

Aromaticity 0.0253

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3717.13

LogP -42.97

H-bond Donors 132.0

H-bond Acceptors 130.0

Rotatable Bonds 303.0

Heavy Atoms 610.0

Ring Count 10.0

Amide Bonds 87.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0038583 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KT7/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0051252 VERIFIED: NO