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MYP_141384
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
20 amino acids
C107H160N22O26S3
Standard
Sequence
LEAIPMCIPPECAFNKPFVF
Physicochemical Analysis
2266.74 Da
4.53
-1.26
-1.49
-0.0628
0.76
0.22
0.38
60.84
83.00
0.1500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
724.77
-1.46
23.0
28.0
65.0
158.0
7.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074021 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 55.0%, C 45.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0125539 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VIRIP-derived peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-12
Disulfide bond between Cys7 and Cys12
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1
1±0.21 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. | Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F. | Cell. 2007 Apr 20;129(2):263-75. | DOI:10.1016/j.cell.2007.02.042 | PMID:17448989 PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0253673 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-12
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of virus infection in P4-CCR5 cells
1±0.21 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0323628 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
VIRIP
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
P4-CCR5
1.00±0.21 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0333205 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
7-12
Bio-Activity Profile
Antimicrobial Antiviral
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/