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MYP_141369
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Basic Information
Brevinin-1CG3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
24 amino acids
C118H205N29O32S2
Standard
Sequence
FLSTLLNVASNVVPTLICKITKKC
Physicochemical Analysis
2606.20 Da
9.39
2.74
2.50
0.1141
0.93
0.57
0.26
14.07
137.92
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
989.22
-8.31
36.0
37.0
86.0
181.0
2.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0288623 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0296987 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22951323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22951323/
RECORD: Rec_0297480 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Toxicity
highly hemolytic to hRBC
19 μM
HC50
PaperCharacterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis
RECORD: Rec_0299291 VERIFIED: YES
Provenance & Taxonomy
Chungan torrent [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID22951323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22951323/
RECORD: Rec_0339027 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Toxic Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
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