Peptide Database

Peptide NameSLAY-screened peptide P1890

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H180N28O24S

DescriptionStandard

        RLPYKFFSGIIRCAVWIIYP
    

Molecular Weight2442.96 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)2.75

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.1374

GRAVY Index0.76

Hydrophobic Moment 0.68

Boman Index0.31

Instability Index21.05

Aliphatic Index 117.00

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 824.94

LogP -0.16

H-bond Donors 31.0

H-bond Acceptors 28.0

Rotatable Bonds 72.0

Heavy Atoms 174.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0266045 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/