Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length466 amino acids

Chemical FormulaC2324H3630N590O682S17

DescriptionStandard

        MLLFVTVVLSLLSCVCGENPAVQVVLTNKGLQYGKHAAADWIQERLSTITFPDITGSVHIIFGDVDYTLTGITIVKCDLPEPSVEFLQNPPGFKTTISDLSIAITGGWRTRFGLIHDGGTFDMAIFNVDVTSVVQLGKEADGHLSVSSISCDSQVGDVDIEFHGGASFIFQPFVEHFKGRIRDEIQKRLCPGVEENIESFENLLHVMNGTAAPNYKEENRGPQISEQNNKITGEFYNIKAPVEPPFEAQPFTMPDEPSYMLSVGMSDFTLNSASYAYFSAKLLQLLINDSMIPAIFPVHLNTTSLGKFIPKLAEMYPDMLMSVLVYAQEAPKFSIQPDAVNVTIKAVAKTSVILPNGTQIPVFTINVDSKFSSELWIDDGKLKGSVKMDNVTLTLASSEVGTFKVNGRLAVWKQCRSFPDLFFSVTEKLGKGFLVLGTKHAQLVNSVLKKEKVGTFRRTHNALVFE
    

Molecular Weight51292.33 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-10.62

Net Charge (pH 7.4) -11.55

Charge Density (pH 7.0) -0.0228

GRAVY Index0.06

Hydrophobic Moment 0.64

Boman Index0.14

Instability Index38.91

Aliphatic Index 93.43

Aromaticity 0.0944

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35785.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225465 VERIFIED: NO

Provenance & Taxonomy

OrganismNeolamprologus brichardi [Bacterium]

FamilyBPI

Tax ID32507

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence