Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length57 amino acids

Chemical FormulaC253H410N72O88S7

DescriptionStandard

        MNKDFDLNLKIAKSTDKDVKPQVTSVAYCTPGCNTGSTCGTSECGLTRNCTNTWLCG
    

Molecular Weight6092.85 Da

Isoelectric Point (pI)7.54

Net Charge (pH 7.0)0.44

Net Charge (pH 7.4) 0.13

Charge Density (pH 7.0) 0.0078

GRAVY Index-0.42

Hydrophobic Moment 0.64

Boman Index-0.05

Instability Index24.21

Aliphatic Index 52.98

Aromaticity 0.0526

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2611.39

LogP -37.09

H-bond Donors 96.0

H-bond Acceptors 96.0

Rotatable Bonds 200.0

Heavy Atoms 420.0

Ring Count 6.0

Amide Bonds 62.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009328 VERIFIED: NO

Provenance & Taxonomy

OrganismPaenibacillus ottowii [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence