Peptide Database

Peptide NameIL-25

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length145 amino acids

Chemical FormulaC723H1125N227O210S12

DescriptionStandard

        YSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG
    

Molecular Weight16741.84 Da

Isoelectric Point (pI)8.74

Net Charge (pH 7.0)5.38

Net Charge (pH 7.4) 4.59

Charge Density (pH 7.0) 0.0371

GRAVY Index-0.79

Hydrophobic Moment 0.81

Boman Index-0.20

Instability Index68.28

Aliphatic Index 62.48

Aromaticity 0.0759

Extinction Coeff. Reduced 26930.00

Extinction Coeff. Oxidized 27555.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6982.10

LogP -75.74

H-bond Donors 255.0

H-bond Acceptors 235.0

Rotatable Bonds 527.0

Heavy Atoms 1172.0

Ring Count 37.0

Amide Bonds 153.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0199864 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residue at position 104; predicted disulphide bond formation between cysteine residues at positions 78 and 136, and 183 and 138.

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

TargetInterleukin-25 receptor (Human)