Peptide Database

Peptide NamePE1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC54H96N12O11

DescriptionStandard

        KIKFLKVLT
    

Molecular Weight1089.41 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.3063

GRAVY Index0.74

Hydrophobic Moment 0.31

Boman Index0.14

Instability Index-28.84

Aliphatic Index 162.22

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 394.41

LogP 0.08

H-bond Donors 14.0

H-bond Acceptors 14.0

Rotatable Bonds 39.0

Heavy Atoms 77.0

Ring Count 1.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0046882 VERIFIED: NO

Provenance & Taxonomy

OrganismBacteria [Bacterium]

Tax ID2

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0354189 VERIFIED: YES

Provenance & Taxonomy

OrganismPaenibacillus ehimensis [Bacterium]

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermLipidation

C-TermEsterification

Other ModsAn N-terminal lipidated cyclic antibiotic with nonstandard amino acid Dab at positions 1, 3, and 6 (Warning: Dab, 2,4-diaminobutanoic acid, is two CH2 units less than lysine, although represented by K here in the sequence), D-amino acids for F4 and V7. The ring structure is proposed to occur between the C-terminal carboxylic and hydroxyl group of the N-terminal fatty acid portion. PE1 and PE2 share the same peptide backbone but have different fatty acid chains (C-end-OCHRCH2CO-N-end: R is C4H9 for PE1 and C3H7 for PE2). Because of the same amino acid sequence, PE1 and PE2 share this AP number

Bio-Activity Profile

Function

Antimicrobial Antifungal

Targetidermidis CMCC 26069, Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300, Escherichia coli ATCC 35318, Escherichia coli 5539, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa 5215, and fungus Candida albicans ATCC 10231

Activity1-8 μg/mL

MethodMIC