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MYP_141044
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Basic Information
CA-MA
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C120H190N30O22
Standard
Sequence
KWKLFKKIGIGKFLHSAKKF
Physicochemical Analysis
2404.98 Da
10.78
6.84
6.58
0.3420
-0.31
0.63
-0.01
-14.99
83.00
0.2000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
863.06
-1.61
31.0
30.0
86.0
172.0
6.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208025 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CA-MA / CA-ME / cecropin-magainin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
NCI-H146
15.8 μM
IC50 / MTT-MTS assay
PaperPMID 9352466; initial CA-MA anticancer report PMID9352466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9352466/
RECORD: Rec_0231130 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
RECORD: Rec_0251224 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Cecropin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial
NCI-H146
15.8 μM
IC50
PMID9352466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9352466/
RECORD: Rec_0261899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CA-MA / CA-ME / cecropin-magainin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
Jurkat
30.0 μM
IC50 / MTT-MTS assay
PaperPMID 10675500; CA-MA activity against leukemia cells PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0265516 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10675500/ PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
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