Peptide Database

Peptide NameNL5

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC33H53N9O16

DescriptionStandard

        PAETGQET
    

Molecular Weight831.82 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.04

Net Charge (pH 7.4) -2.10

Charge Density (pH 7.0) -0.2545

GRAVY Index-1.51

Hydrophobic Moment 0.30

Boman Index-0.15

Instability Index46.29

Aliphatic Index 12.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 411.18

LogP -6.38

H-bond Donors 14.0

H-bond Acceptors 14.0

Rotatable Bonds 26.0

Heavy Atoms 58.0

Ring Count 1.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243089 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Replication inhibition

Targetinhibition of strand transfer catalyzed by integrase

Activity2000 μM

MethodIC50

Half-LifeMammalian: >20 h; Yeast: >20 h; E. coli: ?

PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. | Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. | J Med Chem. 2006 Jul 27;49(15):4477-86. | DOI:10.1021/jm060307u | PMID:16854053 PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/

RECORD: Rec_0346052 VERIFIED: YES