Peptide Database

Peptide NameSLAY-screened peptide P3884

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H166N24O30

DescriptionStandard

        LPIREYDFWPVTPLYAYSPP
    

Molecular Weight2424.74 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0619

GRAVY Index-0.24

Hydrophobic Moment 0.21

Boman Index0.21

Instability Index76.03

Aliphatic Index 78.00

Aromaticity 0.2500

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 825.71

LogP -1.26

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 62.0

Heavy Atoms 174.0

Ring Count 11.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128809 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/