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MYP_140947
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Basic Information
Alloferon (4-13)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
10 amino acids
C39H57N17O13
Standard
Sequence
SGHGQHGVHG
Physicochemical Analysis
971.98 Da
6.78
-0.28
-0.64
-0.0278
-1.13
0.18
0.08
-22.11
29.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
474.58
-7.90
16.0
16.0
30.0
69.0
3.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0349180 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HHV-1 clinical strain:inhibition of virus replication in Vero cells
173 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0356308 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells
210 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0359238 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
toxic against Vero
420 μM
Cytotoxicity
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0398491 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Coxsackie virus B2
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0420021 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Entry inhibition
inhibition of virus replication in LLC-MK2 cells
180 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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