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MYP_140791
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Basic Information
Tritrpticin [W 6 5-OH-W]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VRRFPXWWPFLRR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037246 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 6
Bio-Activity Profile
Hemolytic
at 39.8 microM, Human erythrocytes
65 μM
IC50
PMID25178967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25178967/
RECORD: Rec_0124583 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 6
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
04-8 μM
MIC
PMID25178967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25178967/
RECORD: Rec_0158060 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=HTrp=5-hydroxytryptophan; bTA
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
RECORD: Rec_0221791 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 6
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis 168
2 μM
MIC
PMID25178967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25178967/
RECORD: Rec_0245872 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=HTrp=5-hydroxytryptophan; bTA
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
RBC
65 μM
IC50
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
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