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MYP_140790
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Basic Information
Brevinin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
33 amino acids
C142H246N38O44S2
Standard
Sequence
GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
Physicochemical Analysis
3253.83 Da
9.31
2.74
2.50
0.0830
0.55
0.41
0.20
35.74
106.67
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1320.60
-16.01
49.0
49.0
112.0
226.0
1.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242765 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
RECORD: Rec_0243933 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
8 μg/mL
MIC
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
RECORD: Rec_0298069 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 45.5%, E 0.0%, T 24.2%, C 30.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0306975 VERIFIED: YES
Provenance & Taxonomy
Rana porosa brevipoda [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
4 μg/mL
MIC
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
RECORD: Rec_0329301 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
4 μg/mL
MIC
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
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