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MYP_140790
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Basic Information
Brevinin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
33 amino acids
C142H246N38O44S2
Standard
Sequence
GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
Physicochemical Analysis
3253.83 Da
9.31
2.74
2.50
0.0830
0.55
0.41
0.20
35.74
106.67
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1320.60
-16.01
49.0
49.0
112.0
226.0
1.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009839 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda porsa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
8 μg/mL
MIC
PaperBrevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa.
RECORD: Rec_0063575 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMorikawa N., Hagiwara K., Nakajima T.;. "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa."; Biochem. Biophys. Res. Commun. 189:184-190. Evidence URLhttps://www.uniprot.org/uniprotkb/BR2_RANBP/entry
RECORD: Rec_0063650 VERIFIED: YES
Provenance & Taxonomy
Pelophylax porosus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/P32424/entry
RECORD: Rec_0079687 VERIFIED: YES
Provenance & Taxonomy
Pelophylax porosus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0081843 VERIFIED: YES
Provenance & Taxonomy
Rana brevipoda [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID1449472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1449472/
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