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MYP_140755
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Basic Information
Kalata B7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H204N36O41S6
Standard
Sequence
GLPVCGETCTLGTCYTQGCTCSWPICKRN
Physicochemical Analysis
3095.60 Da
7.77
0.70
0.41
0.0242
0.04
0.31
0.09
49.86
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1229.34
-16.15
49.0
48.0
94.0
211.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0323679 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Escherichia coli
40 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0368092 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
60225
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
Escherichia coli
160 μM
MIC
PaperBackbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).
RECORD: Rec_0370092 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Escherichia coli
160 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0389918 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-27
Bio-Activity Profile
Not found Hemolytic
Human red blood cells
PaperPubMed PMID: 17534989 PMID17534989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17534989/
RECORD: Rec_0422112 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
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