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MYP_140755
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Basic Information
Kalata B7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H204N36O41S6
Standard
Sequence
GLPVCGETCTLGTCYTQGCTCSWPICKRN
Physicochemical Analysis
3095.60 Da
7.77
0.70
0.41
0.0242
0.04
0.31
0.09
49.86
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1229.34
-16.15
49.0
48.0
94.0
211.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0281596 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0293478 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
160 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0298429 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic
Candida albicans
160 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0309882 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Pesticidal
Human erythrocytes
55.2±1.3 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/20564013/ PMID20564013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564013/
RECORD: Rec_0323143 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial cyclotide family Host defense
PaperPDB 2M9O structural record; NMR; chain A; residues 1-29
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