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MYP_140755
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Basic Information
Kalata B7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H204N36O41S6
Standard
Sequence
GLPVCGETCTLGTCYTQGCTCSWPICKRN
Physicochemical Analysis
3095.60 Da
7.77
0.70
0.41
0.0242
0.04
0.31
0.09
49.86
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1229.34
-16.15
49.0
48.0
94.0
211.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0148579 VERIFIED: NO
Provenance & Taxonomy
Oldenlandia affinis [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0155386 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic
Candida albicans
40 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0162797 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0162936 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-positive
Staphylococcus aureus
160 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0165026 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
0.625 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
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