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MYP_140755
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Basic Information
Kalata B7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H204N36O41S6
Standard
Sequence
GLPVCGETCTLGTCYTQGCTCSWPICKRN
Physicochemical Analysis
3095.60 Da
7.77
0.70
0.41
0.0242
0.04
0.31
0.09
49.86
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1229.34
-16.15
49.0
48.0
94.0
211.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037908 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-27
Bio-Activity Profile
Not found Hemolytic
PaperPubMed PMID: 17534989 PMID17534989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17534989/
RECORD: Rec_0068443 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Escherichia coli
20 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0076710 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic
Human histiocytic lymphoma U-937/GTB
29 μM
IC50
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0120874 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
0.313 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0126500 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Metal-binding Membrane-Binding Antiparasitic Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
1.25 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7205640 | PubMed PMID 10000000 PMID2866976;7205640;10000000;28669767;205640;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
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