‹ ›
MYP_140711
← PREVIOUS NEXT → BACK
Basic Information
HR2-anti-P
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C172H292N48O61
Standard
Sequence
DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL
Physicochemical Analysis
4008.44 Da
4.20
-4.23
-4.44
-0.1174
-0.18
0.70
-0.00
42.58
138.06
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1819.18
-19.24
59.0
57.0
143.0
281.0
0.0
42.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0103597 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG8-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of pseudovirus infection in Huh-7 cells
0.0208 μM
IC50
PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
RECORD: Rec_0108724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG8-K(Chol)
PEG8-K(Chol)
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 D614G | protein-mediated cell; -cell
0.0004±0.00004 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
RECORD: Rec_0109344 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome coronavirus 2 [Virus]
Synthetic antiviral peptide
2697049
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2 S943P
0.075 μM
IC90
PaperInhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the SARS-CoV-2 spike glycoprotein HRC domain PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/
RECORD: Rec_0113865 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV:inhibition of cell-cell fusion in Huh-7 cells
0.52±0.11 μM
IC50
PMID30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30989115/
RECORD: Rec_0115752 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells
2.81 μM
IC50
PMID30989115;32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30989115/
FIRST PREV 1 ... 3 4 5 6 7 ... 15 NEXT LAST
Showing 5 records on this page · Page 5 of 15