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MYP_140636
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Basic Information
Lactoferrampin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibitory
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
20 amino acids
C109H181N31O29
Standard
Sequence
DLIWKLLSKAQEKFGKNKSR
Physicochemical Analysis
2389.79 Da
10.17
3.76
3.55
0.1880
-1.02
0.58
-0.30
32.11
83.00
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1025.25
-8.21
36.0
33.0
87.0
169.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018823 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrampin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Reverse transcriptase inhibitory Anti-HIV-1 Antibacterial Antiparasitic
Leishmania donovani; Leishmania pifanoi
MIC
PaperEnhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin | Silva, T. et al. | DOI: 10.1007/s00726-012-1304-0 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0022986 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Reverse transcriptase inhibitory Anti-HIV-1 Antibacterial Anti-Gram-negative Antifungal
Escherichia coli; Candida albicans
2 μM
MIC
PaperA study of effects of peptide fragments of bovine and human lactoferrins on activities of three key HIV-1 enzymes | Wong, JH. et al. | DOI: 10.1016/j.peptides.2014.07.006 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0106810 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrampin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Reverse transcriptase inhibitory Anti-HIV-1 Antibacterial Antifungal
Candida albicans
MIC
PaperLactoferrampin, an antimicrobial peptide of bovine lactoferrin, exerts its candidacidal activity by a cluster of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part | Van Der Kraan, MIA. et al. | DOI: 10.1515/BC.2005.017 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0112976 VERIFIED: YES
Provenance & Taxonomy
Oncorhynchus mykiss [Animal]
Transferrin
8022
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
0.8 μM
LC50
PMID17485465 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17485465/
RECORD: Rec_0183928 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrampin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Reverse transcriptase inhibitory Anti-HIV-1 Antibacterial
MIC
PaperLactoferrin derived peptides antimicrobial activity: an in vitro experiment | Biasibetti, E. et al. | DOI: 10.1080/14786419.2020.1821017 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
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