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MYP_140533
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Basic Information
Cecropin A
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Gene expression inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C184H312N52O47
Standard
Sequence
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK
Physicochemical Analysis
4004.77 Da
10.39
5.76
5.54
0.1556
-0.07
0.80
0.04
16.52
108.11
0.0541
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1629.15
-12.59
55.0
53.0
141.0
283.0
4.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076841 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperEur J Biochem. 1982 Sep;127(1):207-17. | http://www.ncbi.nlm.nih.gov/pubmed/7140755 PMID7140755 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7140755/
RECORD: Rec_0085871 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin/Melittin hybrid
7123
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
>50 μM
LC50; MTT assay
PMID15513914 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15513914/
RECORD: Rec_0095166 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin/Melittin hybrid
7123
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum F32 Tanzania
Percent inhibition; Microscopy (Acridine orange staining)
PaperAll-D amino acid-containing channel-forming antibiotic peptides PMID1693777 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1693777/
RECORD: Rec_0102334 VERIFIED: YES
Provenance & Taxonomy
Antheraea pernyi [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
RT4
96.22 μg/mL
IC50
PMID18315881 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18315881/
RECORD: Rec_0111855 VERIFIED: YES
Provenance & Taxonomy
Giant silk [Animal]; Insecta [Animal]
Cecropin
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID1500163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1500163/
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