Peptide Database

Peptide NameCardioactive peptide

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC42H58N10O12S2

DescriptionStandard

        PFCNAFTGC
    

Molecular Weight959.10 Da

Isoelectric Point (pI)5.87

Net Charge (pH 7.0)-0.06

Net Charge (pH 7.4) -0.15

Charge Density (pH 7.0) -0.0068

GRAVY Index0.69

Hydrophobic Moment 0.35

Boman Index0.37

Instability Index20.86

Aliphatic Index 11.11

Aromaticity 0.2222

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 345.45

LogP -4.05

H-bond Donors 14.0

H-bond Acceptors 14.0

Rotatable Bonds 26.0

Heavy Atoms 66.0

Ring Count 3.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0368433 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyCCAP

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-9

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0370602 VERIFIED: YES

Provenance & Taxonomy

OrganismManduca sexta [Animal]

FamilyCCAP

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-9

Bio-Activity Profile

Function

Hormone Neuropeptide signaling

TargetCCAP peptide conformation (PDB 1V46)

MethodSolution NMR structure determination

RECORD: Rec_0391317 VERIFIED: NO

Provenance & Taxonomy

OrganismCarcinus maenas [Animal]

FamilyCardioactive peptide

Tax ID6759

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-9

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: >20 hour; Yeast: >20 hour; E. coli: ?

RECORD: Rec_0409198 VERIFIED: YES

Provenance & Taxonomy

OrganismDrosophila melanogaster [Animal]

FamilyCCAP

Tax ID7227; 0

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-9

Bio-Activity Profile

Function

Hormone Neuropeptide signaling

TargetCCAP peptide conformation (PDB 1Y49)

MethodSolution NMR structure determination

RECORD: Rec_0419600 VERIFIED: NO

Provenance & Taxonomy

OrganismCallinectes sapidus [Animal]

FamilyCCAP

Tax ID6763

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-9

Bio-Activity Profile

Function

Neuropeptide Cardioactive

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