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MYP_140319
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Basic Information
Tyrocidine B1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
10 amino acids
C69H92N14O14
Standard
Sequence
FPWFNQYVKL
Physicochemical Analysis
1341.55 Da
8.59
0.76
0.55
0.0758
-0.11
0.44
0.26
-1.07
68.00
0.4000
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
464.65
0.40
15.0
15.0
38.0
97.0
6.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249995 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Micrococcus luteus NCTC 8340
8.9 μM
MIC
PMID17462586;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0267937 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Listeria monocytogenes B73-MR1
6.7 μM
IC50
PMID17462586;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0288299 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
24.0 μM
LC50
PMID17462586;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0291867 VERIFIED: YES
Provenance & Taxonomy
Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Escherichia coli HB101
250.0 μg/mL
IC50
PMID17462586;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0293944 VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
-
-
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Listeria monocytogenes; Micrococcus luteus; Escherichia coli; Plasmodium falciparum; human tumor cells; human erythrocytes
MIC/IC50 antimicrobial and antiparasitic assays; tumor-cell LC50; erythrocyte HC50
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
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