Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length125 amino acids

Chemical FormulaC611H975N159O179S3

DescriptionStandard

        MILSWCLVLVTFTSTTFGTNPGVQVRLTQKGLEYGRQLGITSLQQKLGSVTIPDFSGSQSVSPIGNVKYSLTNINLVNVGLPKSALDLVPGTGVRLSIGDAFMNLHGDWRVKYLYVIKDSGSFDV
    

Molecular Weight13508.43 Da

Isoelectric Point (pI)9.21

Net Charge (pH 7.0)2.58

Net Charge (pH 7.4) 2.28

Charge Density (pH 7.0) 0.0206

GRAVY Index0.21

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index23.64

Aliphatic Index 105.84

Aromaticity 0.0880

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5416.14

LogP -54.88

H-bond Donors 189.0

H-bond Acceptors 186.0

Rotatable Bonds 443.0

Heavy Atoms 952.0

Ring Count 19.0

Amide Bonds 136.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207067 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius kuhntae [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria