Peptide Database

Peptide NameMIP(M11A)

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC82H112N20O18

DescriptionStandard

        PRFWEYWLRLAE
    

Molecular Weight1665.89 Da

Isoelectric Point (pI)6.70

Net Charge (pH 7.0)-0.03

Net Charge (pH 7.4) -0.10

Charge Density (pH 7.0) -0.0026

GRAVY Index-0.71

Hydrophobic Moment 0.79

Boman Index-0.05

Instability Index20.57

Aliphatic Index 73.33

Aromaticity 0.3333

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 619.64

LogP 0.16

H-bond Donors 24.0

H-bond Acceptors 18.0

Rotatable Bonds 49.0

Heavy Atoms 120.0

Ring Count 7.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412058 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMDM2/MDMX-binding peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Anticancer MDM2/MDMX-binding Cytotoxic

TargetMDM2; MDMX; HCT-116 p53+/+ cells

MethodBinding affinity (Kd) and cell-viability IC50 assays

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