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MYP_140157
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Basic Information
MIP(M11A)
Anticancer
Anticancer ▸ Antitumor
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
12 amino acids
C82H112N20O18
Standard
Sequence
PRFWEYWLRLAE
Physicochemical Analysis
1665.89 Da
6.70
-0.03
-0.10
-0.0026
-0.71
0.79
-0.05
20.57
73.33
0.3333
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
619.64
0.16
24.0
18.0
49.0
120.0
7.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068370 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MDM2; MDMX
65; 12.1 nM
Binding affinity (Kd)
PaperPubMed PMID: 21423613 PMID21423613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21423613/
RECORD: Rec_0076114 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0099990 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Antimicrobial Anticancer
MDM2; MDMX
65; 12.1 nM
Binding affinity (Kd)
PaperPubMed PMID: 21423613 PMID21423613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21423613/
RECORD: Rec_0374945 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 66.7%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Anticancer Antitumor
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0378517 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Anticancer Cytotoxic
HCT-116-p53+/+
0.4 μM
IC50
PaperMIP-derived peptide inhibitors of MDM2/MDMX and p53 reactivation in cancer cells. PMID21423613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21423613/
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