Peptide Database

Peptide NameHill-Knot 1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC149H257N43O41S7

DescriptionStandard

        IKCTASICTQICRILKYKCGYCASASRCVCLK
    

Molecular Weight3531.35 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)5.68

Net Charge (pH 7.4) 5.37

Charge Density (pH 7.0) 0.1777

GRAVY Index0.56

Hydrophobic Moment 0.72

Boman Index0.03

Instability Index32.79

Aliphatic Index 91.56

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1378.00

LogP -14.50

H-bond Donors 58.0

H-bond Acceptors 54.0

Rotatable Bonds 119.0

Heavy Atoms 240.0

Ring Count 2.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0308188 VERIFIED: YES

Provenance & Taxonomy

OrganismHermetia illucens [Animal]

FamilyDefensin

Tax ID343691

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 6538

Activity32 μM

MethodIC50

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