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MYP_140057
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Basic Information
phyllokinin
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Membrane / Ion-channel modulation ▸ Ion channel modulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Standard
11 amino acids
C66H95N17O14
Standard
Sequence
RPPGFTPFRIY
Physicochemical Analysis
1350.57 Da
10.84
1.76
1.55
0.1599
-0.55
0.33
-0.02
61.62
35.45
0.2727
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
492.21
-2.22
17.0
16.0
35.0
97.0
6.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005500 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
phyllokinin
317381
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
11:Sulfotyrosine
Bio-Activity Profile
Vasoactive Vasodilator Receptor modulation
Rat arterial smooth muscle
In vitro arterial smooth-muscle relaxation assay
Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for phyllokinin (Pithecopus hypochondrialis): PMID 16797783 PMID16797783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16797783/
RECORD: Rec_0015304 VERIFIED: NO
Provenance & Taxonomy
Phasmahyla jandaia [Animal]
Phyllokinin/bradykinin-related peptide
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID: 20932854 PMID20932854 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20932854/
RECORD: Rec_0114661 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phyllokinin/bradykinin-related peptide
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
-
Evidence URLhttps://www.uniprot.org/uniprotkb/P84901/entry
RECORD: Rec_0176232 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
phyllokinin
8395
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
3:4-hydroxyproline; 11:Sulfotyrosine
Bio-Activity Profile
Myotropic Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory
Angiotensin-converting enzyme (ACE)
1.6 μM
ACE inhibition Ki assay
Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PMID14612182 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14612182/
RECORD: Rec_0360915 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]; Phyllomedusa hypochondrialis [Animal]; Phasmahyla jandaia [Animal]; Physalaemus nattereri [Animal]
Phyllokinin/bradykinin-related peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
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