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MYP_140055
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Basic Information
Caerin 1.8
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Standard
24 amino acids
C122H203N31O28
Standard
Sequence
GLFKVLGSVAKHLLPHVVPVIAEK
Physicochemical Analysis
2552.11 Da
9.70
1.93
1.62
0.0806
0.86
0.59
0.35
23.86
150.00
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
907.99
-3.21
30.0
32.0
82.0
181.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0252966 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Caerin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID9230483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9230483/
RECORD: Rec_0260277 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Blue-thighed frog,Litoria chloris, Australia
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
PMID9230483;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9230483/
RECORD: Rec_0276035 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer nNOS inhibitor
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0287787 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0314716 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PMID9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9516047/
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