MYP_140043
Medipeptin A
Antimicrobial
Standard
22 amino acids
C89H157N23O30
Standard
TPAAAVVTTVISGAAVTTAKSI
2029.33 Da
8.41
0.40
0.21
0.0181
1.16
0.27
0.42
6.72
115.45
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
833.26
-11.43
30.0
31.0
61.0
142.0
1.0
21.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0104779
VERIFIED: YES
Provenance & Taxonomy
Pseudomonas mediterranea [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lipidation
Esterification
Warning: this peptide contains non-natural amino acids although they are represented using the closest standard 20 amino acids. Specifically, T1, T8, and T17 are dehydrated into Dhb, while Ser12 is dehydrated to Dha. In total, four S/T residues are dehydrated. Residue K20 is Dab (2,4-diaminobutyric acid). Finally, the acyl chain CH3-(CH2)7-CH(OH)-CH2-CO (a C10 fatty acid chain) is attached to the N-terminus. Thus, the entire sequence is CH3-(CH2)7-CH(OH)-CH2-CO-Dhb-Pro-Ala-Ala-Ala-Val-Val-Dhb-Thr-Val-Ile-Dha-Gly-Ala-Ala-Val-Dhb-Thr-Ala-Dab-Ser-Ile. 77.3% similar to Sclerosin (AP02052), also from a Pseudomonas strain
Bio-Activity Profile
Antimicrobial
X. translucens pv. graminis LMG587
4 μg/mL
MIC
RECORD: Rec_0138239
VERIFIED: YES
Provenance & Taxonomy
Pseudomonas mediterranea [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lipidation
Esterification
Warning: this peptide contains non-natural amino acids although they are represented using the closest standard 20 amino acids. Specifically, T1, T8, and T17 are dehydrated into Dhb, while Ser12 is dehydrated to Dha. In total, four S/T residues are dehydrated. Residue K20 is Dab (2,4-diaminobutyric acid). Finally, the acyl chain CH3-(CH2)7-CH(OH)-CH2-CO (a C10 fatty acid chain) is attached to the N-terminus. Thus, the entire sequence is CH3-(CH2)7-CH(OH)-CH2-CO-Dhb-Pro-Ala-Ala-Ala-Val-Val-Dhb-Thr-Val-Ile-Dha-Gly-Ala-Ala-Val-Dhb-Thr-Ala-Dab-Ser-Ile. 77.3% similar to Sclerosin (AP02052), also from a Pseudomonas strain
Bio-Activity Profile
Antimicrobial
X. campestris pv. campestris NCCB92058
16 μg/mL
MIC
RECORD: Rec_0216587
VERIFIED: YES
Provenance & Taxonomy
Pseudomonas mediterranea [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lipidation
Esterification
Warning: this peptide contains non-natural amino acids although they are represented using the closest standard 20 amino acids. Specifically, T1, T8, and T17 are dehydrated into Dhb, while Ser12 is dehydrated to Dha. In total, four S/T residues are dehydrated. Residue K20 is Dab (2,4-diaminobutyric acid). Finally, the acyl chain CH3-(CH2)7-CH(OH)-CH2-CO (a C10 fatty acid chain) is attached to the N-terminus. Thus, the entire sequence is CH3-(CH2)7-CH(OH)-CH2-CO-Dhb-Pro-Ala-Ala-Ala-Val-Val-Dhb-Thr-Val-Ile-Dha-Gly-Ala-Ala-Val-Dhb-Thr-Ala-Dab-Ser-Ile. 77.3% similar to Sclerosin (AP02052), also from a Pseudomonas strain
Bio-Activity Profile
Antimicrobial
bactericidal to Gram+ Staphylococcus aureus subsp. aureus 5334R4, Bacillus cereus ATCC 14579
8 μg/mL
MIC
RECORD: Rec_0307630
VERIFIED: YES
Provenance & Taxonomy
Pseudomonas mediterranea [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lipidation
Esterification
Warning: this peptide contains non-natural amino acids although they are represented using the closest standard 20 amino acids. Specifically, T1, T8, and T17 are dehydrated into Dhb, while Ser12 is dehydrated to Dha. In total, four S/T residues are dehydrated. Residue K20 is Dab (2,4-diaminobutyric acid). Finally, the acyl chain CH3-(CH2)7-CH(OH)-CH2-CO (a C10 fatty acid chain) is attached to the N-terminus. Thus, the entire sequence is CH3-(CH2)7-CH(OH)-CH2-CO-Dhb-Pro-Ala-Ala-Ala-Val-Val-Dhb-Thr-Val-Ile-Dha-Gly-Ala-Ala-Val-Dhb-Thr-Ala-Dab-Ser-Ile. 77.3% similar to Sclerosin (AP02052), also from a Pseudomonas strain
Bio-Activity Profile
Antimicrobial
P. syringae pv. tomato DC3000
8 μg/mL
MIC