Peptide Database

Peptide NameTo-KL37

Function Ontology

Antimicrobial

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC202H332N62O48S

DescriptionStandard

        KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA
    

Molecular Weight4429.25 Da

Isoelectric Point (pI)11.60

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.2097

GRAVY Index-0.75

Hydrophobic Moment 0.98

Boman Index-0.22

Instability Index48.09

Aliphatic Index 84.32

Aromaticity 0.1081

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1854.78

LogP -14.32

H-bond Donors 64.0

H-bond Acceptors 57.0

Rotatable Bonds 158.0

Heavy Atoms 313.0

Ring Count 6.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0265530 VERIFIED: YES

Provenance & Taxonomy

OrganismTalpa occidentalis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other Mods16%; I=G=R=11%. Mol formula: C202H336N59O48S1; Mol Wt: 4429.297; Mol Ex Coeff: 5550; GRAVY: -0.7516. Discovery: Identified via homologous sequence alignment with the conserved âcathelin ?domain ? Chemical modification: the N-terminus of the synthetic peptide is acetylated (XXE) while the C-terminus is amidated (XXA). Whether these modifications occur in the natural form remain established

Bio-Activity Profile

Function

Antimicrobial

TargetEscherichia coli CECT 434

Activity6.25-12.5 μM

MethodMIC