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MYP_140000
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Basic Information
Leucocin A (18-35)[E3R;A7R;H10R;N14,17R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C86H143N37O20
Standard
Sequence
WGRAFSRGVRRLARGGRG
Physicochemical Analysis
2015.29 Da
12.00
5.76
5.56
0.3200
-0.91
1.10
-0.42
38.91
48.89
0.1111
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
965.44
-11.92
39.0
26.0
67.0
143.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0223553 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Fungi: Candida albicans 10231
63.54 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0225334 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Shigella flexneri 51571
15.89 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0233454 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0241997 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Gram-positive bacteria: Staphylococcus aureus 29213
31.77 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0242504 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli O157:H7 CICC 21530
3.97 μM
MIC
PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
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