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MYP_139994
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Basic Information
Thanatin(insects, arthropods, invertebrates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C103H179N35O27S3
Standard
Sequence
GSKKPVPIIYCNRRTGKCQRM
Physicochemical Analysis
2435.94 Da
10.47
5.74
5.50
0.2732
-0.90
0.49
-0.35
39.88
50.95
0.0476
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1038.37
-11.63
39.0
36.0
82.0
168.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0263382 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Thanatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0267345 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
P.acidolactici
20-40 μM
MIC
PMID8577744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
RECORD: Rec_0272061 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
11-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Ascochyta pisi
5-10 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. doi: 10.1073/pnas.93.3.1221. PMID: 8577744. PMID8577744;9760181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
RECORD: Rec_0278248 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Spined soldier bug [Synthetic]
Thanatin
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
11-18
D-thanatin (all D-amino acids) showed similar activity against multiple Gram+ and fungi strains, but became much less active against Gram- bacteria, indicating some chiral configuration is needed (non-membranes?)
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
N. crassa
0.6-1.2 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides
RECORD: Rec_0280752 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
11-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae
0.6-1.2 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. doi: 10.1073/pnas.93.3.1221. PMID: 8577744. PMID8577744;9760181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
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