‹ ›
MYP_139994
← PREVIOUS NEXT → BACK
Basic Information
Thanatin(insects, arthropods, invertebrates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C103H179N35O27S3
Standard
Sequence
GSKKPVPIIYCNRRTGKCQRM
Physicochemical Analysis
2435.94 Da
10.47
5.74
5.50
0.2732
-0.90
0.49
-0.35
39.88
50.95
0.0476
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1038.37
-11.63
39.0
36.0
82.0
168.0
3.0
22.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0009454 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
11-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Erwinia carotovora
10-20 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. doi: 10.1073/pnas.93.3.1221. PMID: 8577744. PMID8577744;9760181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
RECORD: Rec_0017968 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 14.3%, E 38.1%, T 4.8%, C 42.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Antifungal Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0018828 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Spined soldier bug [Synthetic]
Thanatin
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
11-18
D-thanatin (all D-amino acids) showed similar activity against multiple Gram+ and fungi strains, but became much less active against Gram- bacteria, indicating some chiral configuration is needed (non-membranes?)
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Micrococcus luteus
1.2-2.5 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides
RECORD: Rec_0031048 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
11-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Nectria haematococca
1.2-2.5 μM
MIC
PaperStructure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. doi: 10.1073/pnas.93.3.1221. PMID: 8577744. PMID8577744;9760181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
RECORD: Rec_0032877 VERIFIED: YES
Provenance & Taxonomy
Podisus maculiventris [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli 1106
0.6-1.2 μM
MIC
PMID8577744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8577744/
1 2 3 ... 17 NEXT LAST
Showing 5 records on this page · Page 1 of 17