‹ ›
MYP_139867
← PREVIOUS NEXT → BACK
Basic Information
Ranatuerin-2Lb
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
32 amino acids
C140H251N39O41S2
Standard
Sequence
GILSSIKGVAKGVAKNVAAQLLDTLKCKITGC
Physicochemical Analysis
3200.86 Da
9.60
3.74
3.50
0.1168
0.59
0.60
0.19
-1.54
125.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1299.92
-13.81
47.0
47.0
113.0
222.0
0.0
33.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0242360 VERIFIED: YES
Provenance & Taxonomy
Rana luteiventris [Animal]
Frog skin active peptide (FSAP); Ranatuerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0257855 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-32
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
100.0 μM
HC50
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
RECORD: Rec_0264373 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0285493 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Ranatuerin
69834
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
27-32
Disulfide bridge: C27,C32;
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
4 μM
MIC
PaperPeptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens. PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0311587 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 65.6%, E 0.0%, T 21.9%, C 12.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
FIRST PREV 1 2 3 4 5 NEXT LAST
Showing 5 records on this page · Page 3 of 5