Peptide Database

Peptide NameSLAY-screened peptide P5281

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC85H119N17O25S

DescriptionStandard

        ATQENVFLICPYYSY
    

Molecular Weight1811.02 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.21

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0809

GRAVY Index0.14

Hydrophobic Moment 0.15

Boman Index0.26

Instability Index38.21

Aliphatic Index 78.00

Aromaticity 0.2667

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 686.56

LogP -4.14

H-bond Donors 24.0

H-bond Acceptors 25.0

Rotatable Bonds 52.0

Heavy Atoms 128.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0022662 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/