Peptide Database

Peptide NameLingual antimicrobial peptide (LAP, beta defensin, cattle, ruminant, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length42 amino acids

Chemical FormulaC186H332N72O53S7

DescriptionStandard

        QGVRNSQSCRRNKGICVPIRCPGSMRQIGTCLGAQVKCCRRK
    

Molecular Weight4649.53 Da

Isoelectric Point (pI)10.85

Net Charge (pH 7.0)9.70

Net Charge (pH 7.4) 9.40

Charge Density (pH 7.0) 0.2309

GRAVY Index-0.57

Hydrophobic Moment 0.49

Boman Index-0.33

Instability Index75.55

Aliphatic Index 60.24

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2089.66

LogP -29.65

H-bond Donors 81.0

H-bond Acceptors 70.0

Rotatable Bonds 161.0

Heavy Atoms 318.0

Ring Count 2.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0392147 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyDefensin

Tax ID9913

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide9-38; 16-31; 21-39

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida tropicalis 13803

Activity16-32 μg/mL

MethodMIC

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