Peptide Database

Peptide NamePB1-1-15 A L10I,K11D

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC76H121N17O23S

DescriptionStandard

        MDVNPTLLFIDVPAQ
    

Molecular Weight1672.94 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.50

Net Charge (pH 7.4) -2.71

Charge Density (pH 7.0) -0.1665

GRAVY Index0.61

Hydrophobic Moment 0.18

Boman Index0.32

Instability Index33.09

Aliphatic Index 123.33

Aromaticity 0.0667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 634.15

LogP -3.87

H-bond Donors 19.0

H-bond Acceptors 22.0

Rotatable Bonds 50.0

Heavy Atoms 117.0

Ring Count 3.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0401419 VERIFIED: YES

Provenance & Taxonomy

OrganismInfluenza A virus [Virus]

FamilyVirus-derived peptide

Tax ID11320;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsSequence-variant derivative

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetInfluenza A virus (Replication); MDCK

Activity3 μM

MethodELISA

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Manz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/

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